Low Dose Naltrexone (LDN):
Patient Information
What Is Low Dose Naltrexone?
Low Dose Naltrexone (LDN) is a compounded medication derived from naltrexone, originally used to treat opioid and alcohol dependence. At low doses (0.5–4.5 mg), it acts as an immune modulator and anti-inflammatory agent.
Off-Label Use
LDN is prescribed off-label, meaning it is used for conditions not formally approved by the FDA. Off-label prescribing is legal and based on clinical experience and emerging evidence.
How LDN Works
LDN temporarily blocks opioid receptors, causing a rebound effect that increases natural endorphins and reduces inflammation. It also modulates the immune response and may suppress inflammatory cytokines.
Clinical Applications
LDN has shown potential benefits in:
Autoimmune diseases (e.g., RA, lupus, MS)
Chronic pain syndromes (e.g., fibromyalgia, CRPS)
Neurological conditions (e.g., ME/CFS, Parkinson's)
Cancer support (quality of life)
Mental health (ongoing research)
Scientific Evidence
Studies such as those from Stanford University and others have shown reductions in fibromyalgia and Crohn’s symptoms. Clinical trials and observational data continue to support its safety and utility.
Compounded Medication
LDN is not available at standard pharmacies. It must be specially prepared by a compounding pharmacy in the precise dose prescribed.
HSA/FSA Eligibility
LDN is a qualified medical expense under most HSA/FSA plans with a valid prescription.
Common Side Effects
LDN is generally well tolerated. Side effects may include:
Vivid dreams
Headache
Fatigue
GI upset
Rare mood changes or flu-like symptoms
Is LDN Right for You?
If you are struggling with chronic inflammation, autoimmune symptoms, or pain, LDN may be considered as part of your treatment plan. Consultation with a knowledgeable provider is necessary to determine appropriateness.